pentobarbital will reduce the level or outcome of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Impact of coadministering a powerful CYP3A4 inducer with fedratinib has not been examined.
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Contraindicated (1)pentobarbital will lessen the level or influence of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of docetaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
pentobarbital will decrease the level or influence of saxagliptin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
pentobarbital will reduce the level or impact of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
buprenorphine, extended-performing injection and pentobarbital both improve sedation. Keep away from or Use Alternate Drug. Limit use to patients for whom substitute procedure selections are inadequate
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pentobarbital will reduce the extent or influence of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Consider a rise in cannabidiol dosage (based on clinical response and tolerability) when coadministered with a powerful CYP3A4 inducer.
pentobarbital will decrease the extent or impact of parecoxib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
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pentobarbital will minimize the extent or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is a sensitive CYP3A4 substrate. Coadministration with robust or reasonable CYP3A4 inducers is contraindicated.